Isaac N. St. Clair
- Born: 1841, Pennsylvania
- Marriage: Martha (Mattie) Myers
 Noted events in his life were:
• Residence: From 1850 Census, 1850, White Township, Indiana, Pennsylvania. He is living with his grandparents, James and Nancy Miller.
• Occupation: Merchant, 1880, Indiana, Indiana, Pennsylvania. From 1880 Census
• Residence: Living with his grandfather, James Miler, 1880, Indiana, Indiana, Pennsylvania. From 1880 Census
Isaac married Martha (Mattie) Myers. (Martha (Mattie) Myers was born in 1845 in Pennsylvania.)
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